ASSOCIATION OF OBESITY WITH JAK2 V617F GENE MUTATION IN RECURRENT PREGNANCY LOSS

Document Type : Review Article

Authors

1 Prenatal Diagnosis and Fetal Medicine department National Research Centre

2 Institute of Environmental Studies and Research, Ain Shams University

3 Medical Molecular Genetics department, National Research Centre

Abstract

Maternal obesity is one of the factors that have a role in recurrent pregnancy loss ( RPL) . Increased rate of fetal loss in obese pregnant women might be due the mutation in Janus kinase2 gene (V617F). Our aim to explore the association of obesity with JAK2 V617F mutation in recurrent pregnancy loss. The study is carried out on 250 women, the case group have history of recurrent pregnancy loss with a body mass index (BMI) of >24.9kg/m2.Control group consists of women with normal body mass index with at least one live child birth and with no history of pregnancy loss. All of the subjects were investigated for the mutations by using the allele-specific multiplex PCR. In the 250 women in the study, women who were obese and tested positive for JAK2 V617F were 14 %. The case group revealed 9.3% patients who were for JAK2 V617F and had a BMI with mean of 30.9 ±4.3 ,history of live birth were 64 out of 150 with a mean of 1.3 ±0.5. In conclusion the study was able to find a correlation between the increased risk for the occurrence of RPL in obese women and the investigated V617F mutation in the Jak2 gene exon 12 and that obesity could be a risk modifier for that somatic mutation.
 

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