THE USE OF BIOMARKERS TO PREDICT ATTACKS OF SEVERE BRONCHIAL ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Document Type : Review Article

Authors

1 Faculty of Graduate Studies and Environmental Research, Ain Shams University

2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Banha University

Abstract

Introduction: Increased levels of C-reactive protein (CRP) and fibrinogen among asthmatic and Chronic Obstructive Pulmonary Disease (COPD) patients were associated with disease severity and complications.
Aim of the work: To assess the possible relationship between selected variables and hospitalization as unfavorable outcome.
Subjects and methods: 172 subjects had participated in this observational study and grouped into three groups; control, asthmatic and COPD. Blood analysis used for fibrinogen and CRP levels and pulmonary function were measured. Statistical analysis using t-test, ROC, and regression test in order to assess the predictive potential of those variables.
Results: mean of fibrinogen among COPD group (583.24 mg/dL) was significantly higher than control (207 mg/dL), (P

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